Reference Reagents for Mass Spectrometry
Adequate monitoring of instrument performance for proteomic studies requires complex protein reference materials. Whole-cell protein extracts provide the needed complexity. We offer mass spec-compatible whole-cell reference protein extracts from yeast and human cells in a convenient, pre-digested lyophilized form.
For routine reporting on MS instrument sensitivity and dynamic range as well various LC parameters, we recommend use of the 6 x 5 LC-MS/MS Peptide Reference Mix. The product is a mixture of 30 peptides: 6 sets of 5 isotopologues of the same peptide sequence differing only in the number of stable, heavy labeled amino acids incorporated into the sequence. Chromatographically, each of the isotopologues is indistinguishable; however, since they differ in mass, they are clearly resolved by mass spectrometry.
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What are Reference Reagents for Mass Spectrometry?
- Compatibility with LC/MS (lack detergents, salts, etc.)
- High integrity (minimal degradation and non-biological PTMs)
- Compatibility with common sample preparation methods such as proteolysis, PTM enrichment and mass-tag labeling
- Reproducible lot-to-lot protein composition and quantity
